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KMID : 1025520070490050577
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Journal of Animal Science and Technology
2007 Volume.49 No. 5 p.577 ~ p.584
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Analysis of the ADSF/resistin Gene Polymorphism Associated with Carcass Traits in Hanwoo
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Park J. A.
Kang Hye-Kyeong
Chae E.-J.
Seo Kang-Seok
Kim Sang-Hoon
Yun Cheol-Heui
Moon Yang-Soo
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Abstract
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Adipocyte-specific secretory factor(ADSF)/resistin, an hormone, is a small cysteine-rich protein secreted from adipose tissue and ADSF/resistin has been implicated in modulating adipogenesis in human and rodents. Although the exact role of ADSF/resistin in bovine has not been identified, it may have directly or indirectly involved in adipocyte differentiation. The objective of this study was to investigate its DNA polymorphism associated with carcass traits in Korean Native Cattle(Hanwoo). To investigate DNA polymorphism in Hanwoo ADSF/resistin gene, blood samples were taken from 295 Hanwoo steers belonging to progeny testing at Hanwoo Improvement Center in Korea. Seven single nucleotide polymorphisms(SNPs) were found in intron regions but not in any other regions including promoter (1.7kb) and 4 exons. The highest frequency among SNPs was C186A(0.16/0.84) following G964A (0.156/0.884). The significant correlation(P<0.05) between the SNPs and economic traits was found on 764Ains associated with marbling but not from any other SNPs determined. A computer simulation was also conducted to assess the efficiency of marker assisted selection(MAS) versus the conventional breeding scheme. Results revealed that MAS was more efficient as a breeding tool compared to the conventional. In conclusion, ADSF/Resistin gene is one of candidate genes to evaluate the quality, especially marbling score, in Hanwoo.
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KEYWORD
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ADSF /resistin, Hanwoo, Carcass trait, SNP
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